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![JAK2 [V617F] Recombinant Human Protein, JH1 and JH2 Domains 10μg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-650.jpg)
JAK2 [V617F] Recombinant Human Protein, JH1 and JH2 Domains
JAK2 [V617F] Recombinant Human Protein, JH1 and JH2 Domains
Brand: Invitrogen PV4336
Additional Details : Weight : 0.00945kg
Description
JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2. The V617F mutation has been shown to be a cause of polycythemia vera.Specifications
| NP_004963 | |
| Cell Viability, Pharma and Biopharma, Cell Proliferation and Function, Protein Assays and Analysis, Target and Lead Identification and Validation, Kinase Assay | |
| 97.9kDa | |
| 10μg | |
| For research use only. Not for use in diagnostic procedures | |
| JAK2 JH1 JH2 V617F | |
| JAK2 JH1 JH2 V617F was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL AXLtide peptide substrate (KKSRGDYMTMQIG) and trace [32P]-γ-ATP for 10 minutes at 30°C | |
| Amino acids 532-1132; V617F | |
| 18nmoles of phosphate transferred to AXLtide peptide substrate (KKSRGDYMTMQIG) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 4.17μg/mL | |
| GST Tag | |
| Kinase and inhibitors | |
| 70% by SDS-PAGE |
| 0.19mg/mL | |
| 3717 | |
| JAK2 [V617F] Recombinant Human Protein | |
| –80°C | |
| 1 Each | |
| JAK2 [V617F] Recombinant Human Protein | |
| JAK | |
| JAK2 [V617F] Recombinant Human Protein | |
| Human | |
| Baculovirus | |
| Cytoplasmic tyrosine kinase |
For Research Use Only. Not for use in diagnostic procedures.