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Tocris Bioscience™ JNJ 10198409
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Produktkod. 18776356
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18776356 10 mg
18737466 50 mg
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Product Code. 18776356 Supplier Tocris Bioscience™ Supplier No. 6976/10

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Description

Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in reprogramming of human fibroblasts into functional cardiomyocytes, within 9C cocktail.
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Specifications

Kemiskt namn eller material N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
CAS 627518-40-5
Kvantitet 10 mg
Mål PDGF Receptor Inhibitors
Molekylformel C18H16FN3O2
Formel vikt 2273
Renhet 98%
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