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JUN Mouse anti-Human, Mouse, Rat, Clone: 1G6B11, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66313-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828075

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

This antibody is raised against a region of human JUN. Both phosphorylated (p-c-Jun) and unphosphorylated forms of c-Jun, with sizes of 42-45 kDa and 36-39 kDa, respectively are obtain in some experiments.

Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ′leucine-zipper′ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
Specifications

Specifications

JUN
1G6B11
Unconjugated
JUN
Liquid
Jun
JUN Fusion Protein Ag17639
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P05412, P05627, P17325
Activator protein 1, AP 1, AP1, c Jun, JUN, jun oncogene, P39, Proto oncogene c Jun, Transcription factor AP 1
Mouse
IgG1
20 μL
-20°C
Primary
16476, 24516, 3725
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