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Tocris Bioscience™ KIN001-266
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Product Code. 18705586
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2 mg
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18705586 2 mg
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Product Code. 18705586 Supplier Tocris Bioscience™ Supplier No. 6984/2

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Description

Potent and selective Tpl2 (MAP3K8) inhibitor

KIN001-266 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 1.6 nM). It exhibits 6875-fold selectivity over EGFR. In vivo, it inhibits TNF-α production in a LPS-stimulated rat inflammation model. KIN001-266 is orally bioavailable.
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Specifications

Kemiskt namn eller material 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile
CAS 915363-56-3
Kvantitet 2 mg
Mål MAP3K8/Tpl2/COT
Molekylformel C26H25Cl2FN8
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