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Invitrogen™ Kir2.1 (KCNJ2) Monoclonal Antibody (S112)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA527681
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Beskrivning
1 μg/mL of MA5-27681 was sufficient for detection of Kir2.1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 45kDa. No cross-reactivity against Kir2.2 or Kir2.3.
The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
Specifikationer
| Kir2.1 (KCNJ2) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.09% sodium azide; pH 7.4 | |
| P35561, P63252, P63253, Q64273 | |
| Kcnj2 | |
| Fusion protein amino acids 41-64 and 189-428 of mouse Kir2.1. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rhesus Macaque, Rat | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Microarray | |
| S112 | |
| Unconjugated | |
| Kcnj2 | |
| ATFB9; cardiac inward rectifier KIR2.1; cardiac inward rectifier potassium channel; EGK_08925; HHBIRK1; HHIRK 1; HHIRK1; HIRK 1; hIRK1; Inward rectifier K; inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; inward rectifier potassium channel; inward rectifier potassium channel 2; inwardly rectifying potassium channel Kir2.1; IRK 1; IRK1; IRK-1; IRK2; Kcnf1; KCNJ2; KIR2.1; LQT 7; LQT7; Potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium inwardly rectifying channel subfamily J member 2; potassium inwardly-rectifying channel, subfamily J, member 2; potassium voltage-gated channel subfamily J member 2; RBL-IRK1; SQT 3; SQT3 | |
| Mouse | |
| Protein G | |
| RUO | |
| 16518, 29712, 3759, 574189 | |
| -20°C | |
| Liquid |
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