missing translation for 'onlineSavingsMsg'
Läs mer
  1. Home
  2. Products
  3. Proteinanalysreagenser
  4. Bioaktiva små molekyler
  5. STEMCELL Technologies Ku-0063794

STEMCELL Technologies Ku-0063794

Produktkod. 17110192
Encompass_Preferred
Change view
Klicka för att se tillgängliga alternativ
Kvantitet:
5 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Produktkod. Kvantitet
17110192 5 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Denna artikel kan inte returneras. Se returpolicy
Produktkod. 17110192 Leverantör STEMCELL Technologies Leverantörsnummer 73232

Please to purchase this item. Need a web account? Register with us today!

Denna artikel kan inte returneras. Se returpolicy

Beskrivning

mTOR pathway inhibitor; Inhibits mTORC1 and mTORC2 complexes

  • Ku-0063794 is a cell-permeable, selective inhibitor of the serine-threonine kinase mammalian target of rapamycin (mTOR), inhibiting both the mTORC1 and mTORC2 complexes (IC50 = 10 nM)
  • It shows good specificity (> 1000-fold) against 76 other protein kinases or 7 lipid kinases, including PI3 kinases (García-Martínez et al.)
  • Extends the lifespan of Toll-like receptor (TLR)-activated dendritic cells by preserving mitochondrial oxidative phosphorylation (Amiel et al.)
  • Inhibits cell growth by inducing G1-cell cycle arrest in mouse embryonic fibroblasts and human non-small cell lung carcinoma cell lines (García-Martínez et al.; Fei et al.)
  • Inhibits tumor growth in a xenograft model of renal cell carcinoma (Zhang et al.)
  • Reduces keloid (fibroproliferative dermal lesion) volume in an ex vivo keloid organ culture model, and inhibits keloid cell spreading, proliferation, migration, and invasive properties in vitro (Syed et al.)

Specifikationer

CAS 938440-64-3
Kvantitet 5 mg
Molekylformel C25H31N5O4
Renhet ≥98%
Produkttitel
Välj ett problem

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.