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Tocris Bioscience™ KYP 2047
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Produktkod. 18788006
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25 mg
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Produktkod. Kvantitet
18788006 25 mg
18765746 5 mg
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Produktkod. 18788006 Leverantör Tocris Bioscience™ Leverantörsnummer 6272/25

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Beskrivning

High affinity prolyl oligopeptidase inhibitor (Ki = 0.023 nM); anti-angiogenic, neuroprotective and brain penetrant

KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia. In vivo, treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.
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Specifikationer

Kemiskt namn eller material (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
CAS 796874-99-2
Kvantitet 25 mg
Molekylformel C20H25N3O2
Formel vikt 339.44
Renhet 98%
Produkttitel
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