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Eurofins DiscoverX LATS1 Protein, Active

Produktkod. 17320884
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Kvantitet:
10 μg
250 μg
Förpackningsstorlek:
250µg
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Produktkod. 17320884 Leverantör Eurofins DiscoverX Leverantörsnummer 14988

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Beskrivning

Active, N-Terminal GST-tagged, recombinant, human LATS1, amino acid residues 589-end and N-Terminal 6His-tagged, recombinant, human MOBKL1A, full length, for use in Kinase Assays.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

GenBank NM_004690.2 / GenBank BC038112.1

Specifikationer

Formulering mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molekylvikt (g/mol) 90 kDa (LATS1) and 30 kDa (MOBKL1A)
Kvantitet 10 μg
Art Human
Rekombinant Recombinant
Protein Tag N-terminal GST / N-terminal 6His
Uttryckssystem Recombinant enzyme expressed in Sf21 insect cells
Proteinform Truncated
Renhet eller kvalitetsklass Combined ≥66%
Protein LATS1, active
Produkttitel
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