missing translation for 'onlineSavingsMsg'
Läs mer
  1. Home
  2. Products
  3. Rekombinanta proteiner
  4. Eurofins DiscoverX LATS1 Protein, Active

Eurofins DiscoverX LATS1 Protein, Active

Produktkod. 17330884
Encompass_Preferred
Change view
Klicka för att se tillgängliga alternativ
Kvantitet:
10 μg
250 μg
Förpackningsstorlek:
250µg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Produktkod. Kvantitet unitSize
17330884 250 μg 250µg
17320884 10 μg -
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Denna artikel kan inte returneras. Se returpolicy
Produktkod. 17330884 Leverantör Eurofins DiscoverX Leverantörsnummer 14988M

Vänligen för att beställa denna produkten. Behöver du ett Webbkonto? Registrera ditt konto idag!

Denna artikel kan inte returneras. Se returpolicy

Beskrivning

Active, N-Terminal GST-tagged, recombinant, human LATS1, amino acid residues 589-end and N-Terminal 6His-tagged, recombinant, human MOBKL1A, full length, for use in Kinase Assays.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

GenBank NM_004690.2 / GenBank BC038112.1

Specifikationer

Formulering mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molekylvikt (g/mol) 90 kDa (LATS1) and 30 kDa (MOBKL1A)
Kvantitet 250 μg
Art Human
Rekombinant Recombinant
Protein Tag N-terminal GST / N-terminal 6His
Uttryckssystem Recombinant enzyme expressed in Sf21 insect cells
Proteinform Truncated
Renhet eller kvalitetsklass Combined ≥66%
Protein LATS1, active
Produkttitel
Välj ett problem

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.