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  5. Tocris Bioscience™ LDN 193189 dihydrochloride

Tocris Bioscience™ LDN 193189 dihydrochloride

Produktkod. 18075802
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18075802 1 mg
18707806 10 mg
18787766 50 mg
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Produktkod. 18075802 Leverantör Tocris Bioscience™ Leverantörsnummer 6053/1

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1622.24 SEK valid until 2026-06-30
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Beskrivning

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits 200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634). LDN 193189 synthesized to Ancillary Material Grade also available. For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
CAS 1435934-00-1
Synonym 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Kvantitet 1 mg
Löslighet Soluble to 50 mM aq. soln. and to 20 mM in DMSO
Mål BMP and Other Activin Receptor Inhibitors
Molekylformel C25H22N60.2 HCl
Formel vikt 479.4
Fysisk form Solid
Färg Orange
Produkttyp Bioactive Small Molecule
Renhet 98%
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For Research Use Only.

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