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STEMCELL Technologies LDN193189 (Dihydrochloride)
BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6
3400.65 SEK - 13682.25 SEK
Specifications
| CAS | 1435934-00-1 |
|---|---|
| Synonym | DM-3189 |
| Molecular Formula | C25H22N6 · 2HCl |
| Purity | >98% |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17120032
|
STEMCELL Technologies
72147 |
10 mg |
3400.65 SEK
10mg |
Estimated Shipment: 31-07-2024 Log in to see stock. |
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|
17130032
|
STEMCELL Technologies
72149 |
50 mg |
13682.25 SEK
50mg |
Estimated Shipment: 31-07-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
- LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC50 = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.) It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.) This product is supplied as the dihydrochloride salt of the molecule and it is the most soluble version of LDN193189
- Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.)
- Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.)
- Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.)
- Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.)
- Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.)
- Prevents ovarian cancer cell proliferation (Tsai et al.)
Specifications
| 1435934-00-1 | |
| DM-3189 | |
| C25H22N6 · 2HCl | |
| >98% |