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LIG4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12695-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840554

  • 3313.85 SEK / 150µL
Estimated Shipment: 05-10-2022
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Description

Description

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
Specifications

Specifications

LIG4
Polyclonal
Unconjugated
LIG4
DNA ligase 4, DNA ligase IV, LIG4, ligase IV, DNA, ATP dependent
Rabbit
Antigen Affinity Chromatography
RUO
290907, 319583, 3981
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.21 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P49917, Q8BTF7
Lig4
LIG4 Fusion Protein Ag3385
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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Special Offers

Special Offers