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LIMPII Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 27102-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16825395

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Specifications

Specifications

LIMPII
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O35114, Q14108
AMRF, CD36 antigen like 2, CD36L2, HLGP85, LGP85, LIMP II, limp2, LIMPII, Lysosome membrane protein 2, Lysosome membrane protein II, SCARB2, SR BII
Rabbit
IgG
20 μL
-20°C
Primary
12492, 950
Western Blot, Immunohistochemistry (Paraffin)
Unconjugated
SCARB2
Liquid
SCARB2
LIMPII Fusion Protein Ag25908
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human
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