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  5. Tocris Bioscience™ LIN28 1632, >98%

Tocris Bioscience™ LIN28 1632, >98%
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Produktkod. 30000886
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30000886 10 mg
30000860 50 mg
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Produktkod. 30000886 Leverantör Tocris Bioscience™ Leverantörsnummer 6068/10

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Beskrivning

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity . Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.
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Specifikationer

Kemiskt namn eller material N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
CAS 108825-65-6
Kvantitet 10 mg
Löslighet Soluble to 100mM in DMSO and to 100mM in ethanol
Molekylformel C15H15N5O
Formel vikt 281.31
Renhet >98%
Molekylvikt (g/mol) 281.319
Produkttitel
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