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Tocris Bioscience™ LYN 1604 dihydrochloride
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Produktkod. 18747706
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50 mg
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Produktkod. Kvantitet
18747706 10 mg
18748106 50 mg
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Produktkod. 18747706 Leverantör Tocris Bioscience™ Leverantörsnummer 6617/10

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Beskrivning

Potent UNC-51-like kinase 1 (ULK1) agonist

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.
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Specifikationer

Kemiskt namn eller material 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride
CAS 2310109-38-5
Kvantitet 10 mg
Mål ULK1
Molekylformel C33H43Cl2N3O2.2HCl
Produkttitel
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