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MBD4 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11270-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828233

  • 1211.96 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Specifications

Specifications

MBD4
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O95243, Q9Z2D7
MBD4, MED1
Rabbit
IgG
20 μL
-20°C
Primary
17193, 8930
Western Blot
Unconjugated
MBD4
Liquid
Mbd4
MBD4 Fusion Protein Ag1822
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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