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MCL-1 Monoclonal Antibody (LVUBKM), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
3650.00 SEK
Specifications
Clone | LVUBKM |
---|---|
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugate | Alexa Fluor 488 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15520267
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Affymetrix eBioscience
53-9047-42 |
100 Tests |
3650.00 SEK
100 tests |
In Stock Log in to see stock. |
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Description
Description: This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintece of mature lymphocytes. Applications Reported: This LVUBKM antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This LVUBKM antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
MCL-1 Monoclonal antibody specifically detects MCL-1 in Human, Mouse samples. It is validated for Flow Cytometry.Specifications
LVUBKM | |
Flow Cytometry | |
Alexa Fluor 488 | |
Mouse | |
Human, Mouse | |
MCL1 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
MCL1 |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
17210, 4170 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.