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MCPT-1 (mMCP-1) Rat anti-Mouse, Clone: RF6.1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5503-80

Additional Details : Weight : 0.01000kg

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Product Code. 15207427

  • 894.00 SEK / 25µg


Estimated Shipment
30-11-2020
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Description

Description

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.
Specifications

Specifications

MCPT-1 (mMCP-1)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P11034
Mcpt1
IgG1
25 μg
4° C
Primary
17224
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
RF6.1
Unconjugated
Mcpt1
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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