MCPT-1 (mMCP-1) Rat anti-Mouse, Clone: RF6.1, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-5503-82
Additional Details : Weight : 0.01000kg
DescriptionIt is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.
|PBS with 0.09% sodium azide; pH 7.2|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry|
For Research Use Only.