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MD-2, clone: 9B4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9928-80

Additional Details : Weight : 0.01000kg

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Product Code. 15258247

  • 936.00 SEK / 25µg


Estimated Shipment date
from Supplier 20-08-2018
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Description

Description

Description: The 9B4 antibody reacts with human MD-2, an approximately 30kDa molecule, which physically associates with the extracellular domain of TLR4. MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4 since in MD-2(-/-) embryonic fibroblasts, TLR4 was not able to reach the plasma membrane and predominantly resided in the Golgi apparatus, whereas TLR4 was distributed at the leading edge surface of cells in wild-type embryonic fibroblasts. MD-2(-/-) mice do not respond to LPS, do survive endotoxic shock but are susceptible to Salmonella typhimurium infection.Applications Reported: The 9B4 antibody has been reported for use in immunoprecipitation.Applications Tested: This 9B4 antibody has been tested by immunoprecipitation of recombinant MD-2 from cell supernatant. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

MD-2
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9Y6Y9
MD-2
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunoprecipitation
9B4
Unconjugated
LY96
Purified
LY96
IgG1
25μg
Store at 2-8°C.
Primary
23643
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