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Gibco™ MDR1 Vesicular Transport Assay Reagent Set

The MDR1 Vesicular Transport Assay Reagent Set is a ready-to-use kit containing all reagents needed for vesicular transport assay except for the vesicles themselves.

Brand:  Gibco™ GM3030

Product Code. 10518760

  • 5190.00 SEK / Each
Estimated Shipment: 29-10-2024
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Description

Description

The MDR1 Vesicular Transport Assay Reagent Set is a ready-to-use kit containing all reagents needed for vesicular transport assay except for the vesicles themselves. The reagent set can be used for vesicular transport assay using radioisotope-labeled or non-labeled compound. This kit has enough material to perform 100 vesicular transport assays.

Use The MDR1 Vesicular Transport Assay Reagent Set to:

  • Investigate the transporter interactions of your drug candidates
  • Assess potential for transporter-mediated drug-drug interactions
  • Obtain high quality results with a large signal to noise ratios

Concept Behind ABC Transporter Vesicles

ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate's substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.

Clear and Reliable Results

Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these 'inside-out' vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.

Kit Compatibility

Our MDR1 Vesicular Transport Assay Reagent Set is designed for use with MDR1 Vesicles. The 100 vesicular transport assays that can be performed with this kit will require two MDR1 Vesicle products.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Store Reagents A, B, C, and D at -20°C
Store Reagents E and F at room temperature
Pharma and biopharma, target and lead identification and validation, drug discovery and development, target-Based ADME/Tox assays, biochemical ADME assays, cytochrome P450 inhibition ADME assays
100 Assays
Vesicular Transport Assay Reagent Set
MDR1 Vesicular Transport Assay Reagent Set, 100 Assays, Frozen, Bottle Format, Ready-to-Use Kit, Obtain High Quality Results With a Large Signal to Noise Ratios, –20°C Storage Temperature, Dry Ice Shipping Condition
Buffer A: Reaction Buffer (6mL x 1 vials): 50mM MOPS-Tris, 70mM KCl, 7.5mM MgCl2, Buffer B: x10 stopping and washing buffer (20mL x 1 vials) - 400mM MOPS-Tris, 700mM KCl, reagent C: 10mM MgATP solution (1.1mL x 2 vials), reagent D: 10mM MgAMP solution (1.1mL x 2 vials), reagent E: 10% (w/v) SDS solution (13mL x 1 vial), reagent F: 0.1N H2SO4 solution (11mL x 1 vial)
Dry Ice
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For Research Use Only. Not for use in diagnostic procedures.