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MERTK Monoclonal Antibody (DS5MMER), APC-eFluor™ 780, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen 47-5751-80

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Product Code. 16616374

  • 1850.00 SEK / Pack of 2

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Description

Description

MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MERTK
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q60805
Mertk
FC-tagged full protein expressed in insect cells
25 μg
Primary
Mouse
Antibody
IgG2a κ
Flow Cytometry
DS5MMER
APC-eFluor 780
Mertk
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Rat
Affinity chromatography
RUO
17289
4° C, store in dark, DO NOT FREEZE!
Liquid
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