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Invitrogen™ Human MET (cMET), His Tag Recombinant Protein

Produktkod. 11549326
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Kvantitet:
1 mg
10 μg
Förpackningsstorlek:
10µg
1mg
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For Research Use Only. All usage must comply with product instructions.

Produktkod. 11549326

Brand: Invitrogen™ PV3143

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Denna artikel kan inte returneras. Se returpolicy

For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic.

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P08581
Koncentration See Label
För användning med (applikation) Kinase Assay
Formulering 20mM tris with 0.5mM EDTA, 100mM NaCl, 2mM DTT, 50% glycerol, 0.05% Triton X-100 and no preservative; pH 7.5
Gen-ID (Entrez) 4233
Molekylvikt (g/mol) 53.7 kDa
Namn Human MET (cMET), His Tag
pH-intervall 7.5
Reningsmetod Purified
Kvantitet 10 μg
Förvaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
Vanligt namn c-Met
Gensymbol MET
KinaseFamily MET (HGFR) Kinase Family
Protein Längd 956-1390
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Protein Tag His-tag
Sekvens 956-1390
Innehåll och lagring -80°C, Avoid Freeze/Thaw Cycles
Analysinträde Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Tyrosine Kinases
Frakt skick Dry Ice
Systemkompatibilitet LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Taggposition N-Terminal
Målinträde MET
Target Gene met proto-oncogene
Uttryckssystem Baculovirus
Proteinfamilj Kinases & Inhibitors
Proteinform Recombinant, Catalytic Domain, Cytoplasmic
Form Liquid
Protein subtyp Receptor Tyrosine Kinases
Forskningskategori Signal Transduction
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