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Invitrogen™ Human MET [M1250T], His Tag Recombinant Protein

Product Code. 10007092
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.
This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
TRUSTED_SUSTAINABILITY

Specifications

Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50 mM tris HCl with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Molecular Weight (g/mol) 53.7 kDa
Name Human MET [M1250T], His Tag
Quantity 1 mg
Regulatory Status RUO - research use only
Common Name MET (M1250T Mutant)
KinaseFamily MET (HGFR) Kinase Family
Protein Length 956-1390; M1250T
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Insect cells
Form Liquid
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