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Invitrogen™ MICA/B Monoclonal Antibody (6D4), Biotin

Beskrivning
This antibody recognizes a common extracellular epitope on MICA and MICB glycoproteins, transmembrane ligands of CD314 (NKG2D), and is able to block CD314-mediated activation of NK cells and cytotoxic T cells.
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
Specifikationer
Specifikationer
| Antigen | MICA/B |
| Användningsområden | Flow Cytometry, Immunoprecipitation, Immunocytochemistry |
| Klassificering | Monoclonal |
| Klona | 6D4 |
| Koncentration | 1 mg/mL |
| Konjugera | Biotin |
| Formulering | PBS with 15 mM sodium azide; pH 7.4 |
| Gen | MICA |
| Genaccessionsnr. | Q29980, Q29983 |
| Gene Alias | HLA class I antigen; MHC class I chain-related protein A; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence A; MHC class I polypeptide-related sequence B; MHC class I related sequence A; MHC class I-like molecule PERB11.2-IMX; MICA; MIC-A; MICB; MIC-B; PERB11.1; PERB11.2; sMICA; sMICB; soluble MICA; soluble MICB; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A |
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Produkttitel
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