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  5. Tocris Bioscience™ ML 252

Tocris Bioscience™ ML 252
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Product Code. 18786716
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Product Code. 18786716 Supplier Tocris Bioscience™ Supplier No. 4687/10

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Description

Potent and selective KV7.2 inhibitor; brain penetrant

ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays >40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 μM for KV7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of >68 GPCRs, ion channels and transporters; inhibits melatonin MT1 receptor 60% at 10 μM. ML 252 is brain penetrant.
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Specifications

Kemiskt namn eller material (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
CAS 1392494-64-2
Kvantitet 10 mg
Mål Voltage-gated Potassium Channel Blockers
Molekylformel C20H24N2O
Renhet 0.98
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