Invitrogen™ P-Selectin (Soluble) Monkey ELISA Kit
For the quantitative detection of monkey sP-selectin.
Brand: Invitrogen™ BMS650-4
Additional Details : Weight : 0.23750kg
DescriptionP-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.
|101009024, 102141875, 701277|
|Serum, 10 μL|Supernatant, 10 μL|
|1 hr. 20 min.|
|Baboon,Cynomolgus Monkey,Rhesus Monkey|
|Granule membrane protein 140, PADGEM, CD62P|
|Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, HRP-conjugated Detection Antibody, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers|
|2°C to 8°C|
|2 hr. 30 min.|
|Colorimetric Microplate Reader|
For Research Use Only