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Gibco™ Mouse GM-CSF Recombinant Protein, PeproTech®

Produktkod. 17812243
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17812243 100 μg 100µg
17852513 1 mg -
17842533 20 μg 20µg
17862713 250 μg -
17802743 500 μg -
17842913 50 μg -
17852533 5 μg -
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Produktkod. 17812243 Leverantör Gibco™ Leverantörsnummer 31503100UG

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Recombinant Protein

Recombinant Murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P01587
För användning med (applikation) ELISA, Functional Assay, Western Blot
Formulering protein with no preservative
Gen-ID (Entrez) 12981
Molekylvikt (g/mol) 14.2 kDa
Namn Mouse GM-CSF
Kvantitet 100 μg
Källa E. coli
Regulatorisk status RUO
Endotoxinkoncentration <1 EU/ μg
Gene Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Vanligt namn GM-CSF
Gensymbol CSF2
Biologisk aktivitet The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg
Konjugera Unconjugated
Rekombinant Recombinant
Sekvens MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK
Innehåll och lagring -20°C
Uttryckssystem E. coli
Form Lyophilized
Renhet eller kvalitetsklass ≥ 98% by SDS-PAGE gel and HPLC analyses.
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