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Invitrogen™ eBioscience™ Mouse Granzyme B Platinum ELISA Kit

For the quantitative detection of mouse Granzyme B

Brand:  Invitrogen™ BMS6029

Additional Details : Weight : 0.23750kg

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Product Code. 15502007

  • 4930.00 SEK / 96 tests


Estimated Shipment date
from Supplier 05-07-2019
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse Granzyme B

Description

Description

Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
Specifications

Specifications

P04187
Biotin
14939
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
96 tests
1.6 pg/mL
50μL
Mouse
1 hr 20 min
Mouse
Granzyme 2, Fragmentin 2, Human lymphocyte protein
3.5%
7.8-500 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA
RUO
Plasma, Serum, Supernatants
Plasma (50μL), Serum (50μL), Supernatants (50μL)
2-8°C
3 hr 30 min
Gzmb
4.1%
HRP
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