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Invitrogen™ IL-17 Mouse ELISA Kit

For the quantitative detection of mouse TNF-alpha.

Brand:  Invitrogen™ BMS6001TEN

Additional Details : Weight : 0.23750kg

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Product Code. 15561957

  • 22670.00 SEK / Pack of 10


Estimated Shipment
14-12-2020
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IL-17
Biotin-Conjugate anti-mouse IL-17 monoclonal antibody
Streptavidin-HRP
Mouse IL-17 Standard lyophilized, 1ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Specifications

Specifications

Q62386
Biotin
16171
ELISA Kit
1.6 pg/mL
Serum, 50 μL|Supernatant, 50 μL
1 hr. 20 min.
Mouse
Interleukin-17, IL-17A, CTLA8
9.1%
Mouse
HRP
7.8-500 pg/mL
ELISA
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
RUO
50 μL
2°C to 8°C
3 hr. 10 min.
Ctla-8,Ctla8,IL-17,IL-17A,Il17
8.5%
10 x 96 Tests
Supernatant
Colorimetric Microplate Reader
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For Research Use Only