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Tocris Bioscience™ MP A08

Produktkod. 18777946
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Kvantitet:
10 mg
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Produktkod. Kvantitet
18777946 10 mg
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Produktkod. 18777946 Leverantör Tocris Bioscience™ Leverantörsnummer 5803/10

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Beskrivning

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
CAS 219832-49-2
Synonym NSC 122314
Kvantitet 10 mg
Mål Sphingosine Kinase Inhibitors
Molekylformel C27H25N3O4S2
Formel vikt 519.64
Produkttitel
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