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Epredia™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody
Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.
1260.00 SEK - 5050.00 SEK
Specifications
| Antigen | MSH2 (Mismatch Repair Protein 2) Ab-1 |
|---|---|
| Clone | 25D12 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Form | Quantity | Price | Quantity & Availability | ||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Form | Quantity | Price | Quantity & Availability | ||||
|
12619936
|
Epredia™
MS-1498-S0 |
Concentrated | 100 μL |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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|
12629936
|
Epredia™
MS-1498-S1 |
Concentrated | 500 μL |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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|
12609936
|
Epredia™
MS-1498-S |
Concentrated | 1 mL |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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|
12689926
|
Epredia™
MS-1498-R7 |
Prediluted | 7 mL |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSβ, which binds to insertion/deletion loops in DNA.Host Species: Mouse
Clone: 25D12
Isotype: IgG1/κ
Species Reactivity: Human. Others not tested.
Immunogen: Recombinant human MSH2 protein
Molecular Weight: ∽102kDa
Positive Control: Tonsil
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Specifications
| MSH2 (Mismatch Repair Protein 2) Ab-1 | |
| Immunohistochemistry (Paraffin) | |
| Unconjugated | |
| IVD | |
| Recombinant human MSH2 protein |
| 25D12 | |
| Monoclonal | |
| Mouse | |
| DNA Repair | |
| Primary |