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Thermo Scientific™ Lab Vision™ MUC-1 Ab-5, Hamster Monoclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

1240.85 SEK - 6191.50 SEK

Specifications

Antigen MUC-1 Ab-5
Clone MH1; same as CT2
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Conjugate Unconjugated
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Products 6
Product Code Brand Formulation Quantity Price Quantity & Availability  
Product Code Brand Formulation Quantity Price Quantity & Availability  
12628606 Thermo Scientific™
HM-1630-P0
Purified Ab with BSA and Azide 100μL 1240.85 SEK
100µL View alternative products
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Estimated Shipment date
from Supplier 16-07-2019
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12638606 Thermo Scientific™
HM-1630-P1
Purified Ab with BSA and Azide 500μL 3452.47 SEK
500µL View alternative products
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Estimated Shipment date
from Supplier 15-07-2019
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12618606 Thermo Scientific™
HM-1630-P
Purified Ab with BSA and Azide 1mL 5763.74 SEK
1mL View alternative products
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Estimated Shipment date
from Supplier 15-07-2019
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12648606 Thermo Scientific™
HM-1630-P1ABX
Ab without BSA/Azide (Frozen) 100μL 3795.02 SEK
100µL View alternative products
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Estimated Shipment date
from Supplier 15-07-2019
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12658606 Thermo Scientific™
HM-1630-PABX
Ab without BSA/Azide (Frozen) 200μL 6191.50 SEK
200µL View alternative products
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Estimated Shipment date
from Supplier 15-07-2019
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12688606 Thermo Scientific™
HM-1630-R7
Ready-to-use for IHC (UVLP) 7mL 2973.56 SEK
7mL View alternative products
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Estimated Shipment date
from Supplier 15-07-2019
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Description

Description

Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.

Host Species: Hamster

Clone: MH1 (CT2)

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 239-255

Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1

Molecular Weight: 14-28kDa

Positive Control: MCF-7 cells; Breast CA

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

MUC-1 Ab-5
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
RUO
Primary
IgG
MH1; same as CT2
Monoclonal
Hamster
Cancer and Tumor Biology
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1