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Myocilin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4B1F6, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 60357-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16827485

  • 1236.20 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24.3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.
Specifications

Specifications

Myocilin
4B1F6
Unconjugated
MYOC
Liquid
Myoc
Myocilin Fusion Protein Ag5492
Protein A
RUO
Antibody
Monoclonal
Mouse, Rat, Human, Porcine
Western Blot, Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O70624, Q99972, Q9R1J4
GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR
Mouse
IgG2a
20 μL
-20°C
Primary
17926, 397046, 4653, 81523
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Special Offers

Special Offers