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Myocilin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4B1F6, Proteintech

Mouse Monoclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen Myocilin
Clone 4B1F6
Concentration 1 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16827485
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Proteintech
60357-1-IG-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 03-04-2024
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16817485
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Proteintech
60357-1-IG-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 03-04-2024
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Description

Description

Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24.3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.
Specifications

Specifications

Myocilin
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR
Myoc
IgG2a
Protein A
Antibody
4B1F6
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Mouse
Human, Mouse, Porcine, Rat
O70624, Q99972, Q9R1J4
17926, 397046, 4653, 81523
Myocilin Fusion Protein Ag5492
Primary
-20°C
MYOC
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SDS
Documents

Documents

Product Certifications