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Myocilin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4B1F6, Proteintech
Mouse Monoclonal Antibody
1656.73 SEK - 4721.67 SEK
Specifications
Antigen | Myocilin |
---|---|
Clone | 4B1F6 |
Concentration | 1 mg/mL |
Applications | Immunohistochemistry (Paraffin), Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16827485
|
Proteintech
60357-1-IG-20UL |
20 μL |
1656.73 SEK
20µL |
Estimated Shipment: 03-04-2024 Log in to see stock. |
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16817485
|
Proteintech
60357-1-IG-150UL |
150 μL |
4721.67 SEK
150µL |
Estimated Shipment: 03-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24.3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.Specifications
Myocilin | |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR | |
Myoc | |
IgG2a | |
Protein A | |
Antibody |
4B1F6 | |
Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
Mouse | |
Human, Mouse, Porcine, Rat | |
O70624, Q99972, Q9R1J4 | |
17926, 397046, 4653, 81523 | |
Myocilin Fusion Protein Ag5492 | |
Primary | |
-20°C | |
MYOC |