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N-cadherin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 22018-1-AP-20UL
This item is not returnable.
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Description
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin′s function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.Specifications
N-cadherin | |
Polyclonal | |
Unconjugated | |
CDH2 | |
Cadherin 2, CD325, CDH2, CDHN, CDw325, N cadherin, NCAD, N-cadherin, Neural cadherin | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
1000, 12558, 83501 | |
-20°C | |
Liquid |
Immunoprecipitation, Immunocytochemistry, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence | |
0.35 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P15116, P19022, Q9Z1Y3 | |
Cdh2 | |
N-cadherin Fusion Protein Ag16792 | |
20 μL | |
Primary | |
Mouse, Human, Rat | |
Antibody | |
IgG |