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NEDD4L Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 13690-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
This antibody can recognize NEDD4-1 and NEDD4-2.
NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.Specifications
| NEDD4L | |
| Polyclonal | |
| Unconjugated | |
| NEDD4L | |
| hNedd4 2, KIAA0439, NEDD4 2, NEDD4.2, NEDD4L, NEDL3, RSP5 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 23327, 291553, 83814 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot, Immunofluorescence | |
| 0.13 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q8CFI0, Q96PU5 | |
| Nedd4l | |
| NEDD4L Fusion Protein Ag4565 | |
| 20 μL | |
| Primary | |
| Mouse, Rat, Human | |
| Antibody | |
| IgG |