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NEDD4L Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 13690-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16822044

  • 1236.20 SEK / 20µL
Estimated Shipment: 02-12-2021

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Description

Description

This antibody can recognize NEDD4-1 and NEDD4-2.

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
Specifications

Specifications

NEDD4L
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8CFI0, Q96PU5
hNedd4 2, KIAA0439, NEDD4 2, NEDD4.2, NEDD4L, NEDL3, RSP5
Rabbit
IgG
20 μL
-20°C
Primary
23327, 291553, 83814
Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot, Immunofluorescence
Unconjugated
NEDD4L
Liquid
Nedd4l
NEDD4L Fusion Protein Ag4565
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Rat, Human
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