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  5. Tocris Bioscience™ Nexinhib20

Tocris Bioscience™ Nexinhib20
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Product Code. 18778446
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25 mg
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18778446 5 mg
18769976 25 mg
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Product Code. 18778446 Supplier Tocris Bioscience™ Supplier No. 6089/5

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Description

Rab27 inhibitor (IC50 = 330 nM); inhibits neutrophil exocytosis; active in vivo

Nexinhib20 is a Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.
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Specifications

Kemiskt namn eller material 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
CAS 331949-35-0
Kvantitet 5 mg
Molekylformel C15H16N4O3
Formel vikt 300.31
Renhet 98%
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