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NKG2A/C/E Rat anti-Mouse, FITC, Clone: 20d5, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-5896-82

Additional Details : Weight : 0.25000kg

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Product Code. 15238289

  • 1100.00 SEK / 100µg

Estimated Shipment
21-07-2021

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Description

Description

Description: The 20d5 monoclonal antibody reacts with the mouse NKG2A, C, and E. NKG2 molecules belong to a C-type lectin-like family of cell surface receptors expressed by mouse NK and NKT cell lineages. NKG2 molecules form heterodimeric complexes with CD94 and are responsible for recognition of non-classical MHC class I antigen Qa-1. When co-staining with NKG2A^B6 clone 16a11, it is important to stain for NKG2A-B6 first then subsequently with NKG2A/C/E, as steric hindrance has been observed if co-stained concurrently. Applications Reported: 20d5 has been reported for use in flow cytometric analysis. Applications Tested: The 20d5 antibody has been tested by flow cytometric analysis of mouse splenocytes and can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
Specifications

Specifications

NKG2A/C/E
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Liquid
Klrc1, Klrc2, Klrc3
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16641, 16642, 58179
Flow Cytometry
20d5
FITC
Klrc2
CD159A, NKG2, NKG2A, C-lectin type II protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-1/B activating NK receptor, NKG2-A/B type II integral membrane protein, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein, natural killer cell l, KLRC1, cd159e, cd159c
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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For Research Use Only.