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Nod2 Monoclonal Antibody (26mNOD2), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5858-82

Additional Details : Weight : 0.01000kg

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Product Code. 15277517

  • 3715.00 SEK / 100µg
Estimated Shipment: 08-05-2024
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Description

Description

Description: The monoclonal antibody 26mNOD2 reacts with mouse NOD2. NOD2, also referred to as caspase recruitment domain-containing protein 15 (CARD 15), is a cytosolic protein of approximately 115kDa. NOD2 contains a central NOD (nucleotide oligomerization domain) that is flanked by a C-terminal leucine-rich repeat (LRR) domain and an N-terminal CARD domain. The LRR confers recognition of microbial components such as muramyl dipeptide and the CARD domain confers the ability to interact with RIP2 via homotypic interaction with the RIP2 CARD. This interaction leads to downstream activation of NF-kappaB. The antibody 26mNOD2 has been shown to recognize protein from transgenic and transfected cells. Refer to references for expression in endogenous cells. Applications Reported: This 26mNOD2 antibody has been reported for use in immunoblotting (WB). Applications Tested: This 26mNOD2 antibody has been tested by immunoblotting of lysates of 293T cells transfected with mouse NOD2. This antibody has been validated on transfected cell lines and cells from NOD2-transgenic mice. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.
Specifications

Specifications

Nod2
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q8K3Z0
NOD2
Affinity chromatography
RUO
257632
4° C
Liquid
Western Blot
26mNOD2
Unconjugated
NOD2
ACUG; BLAU; CARD15; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; CD; CLR16.3; F830032C23Rik; IBD1; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; Nlrc2; NOD 2; NOD2; NOD-2; NOD2 protein; NOD2B; NOD-like receptor C2; nucleotide binding oligomerization domain containing 2; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; nucleotide-binding oligomerization domain-containing protein 2; PSORAS1
Rat
100 μg
Primary
Mouse
Antibody
IgG1 κ
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