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NRG1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10527-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16876963

  • 1236.20 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Specifications

Specifications

NRG1
0.44 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q02297
ARIA, GGF, GGF2, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, neuregulin 1, NRG1, Pro NRG1, SMDF
Rabbit
IgG
20 μL
-20°C
Primary
211323, 3084
Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
Unconjugated
NRG1
Liquid
Nrg1
NRG1 Fusion Protein Ag0803
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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