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NRG1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10527-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.Specifications
NRG1 | |
Polyclonal | |
Unconjugated | |
NRG1 | |
ARIA, GGF, GGF2, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, neuregulin 1, NRG1, Pro NRG1, SMDF | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
211323, 3084 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin) | |
0.44 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q02297 | |
Nrg1 | |
NRG1 Fusion Protein Ag0803 | |
20 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |