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NUMB Mouse anti-Human, Mouse, Rat, Clone: 2G12B7, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 60137-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16877105

  • 3313.85 SEK / 150µL
Estimated Shipment: 07-12-2021

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Description

Description

Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71, and P72, but can not recognize NUMBL.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
Specifications

Specifications

NUMB
2G12B7
Unconjugated
NUMB
Liquid
Numb
peptide
Caprylic Acid Precipitation
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P49757, Q2LC84, Q9QZS3
h Numb, NUMB, numb homolog (Drosophila), Protein numb homolog, Protein S171, S171
Mouse
IgG2a
150 μL
-20°C
Primary
18222, 29419, 8650
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Special Offers