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p21 (WAF1, Cip1), Polyclonal, eBioscience™

Rabbit Polyclonal Antibody

Brand:  Affymetrix eBioscience 14-6715-63

Additional Details : Weight : 0.01000kg

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Product Code. 15277937

  • 514.00 SEK / 10µg


EU Stock 2
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Description

Description

Applications Reported: Purified anti-mo/hu/rat p21 (WAF1/Cip1) poly has been reported for use in immunoprecipitation, immunoblotting (WB), and immunohistochemical staining. Applications Tested: Purified anti-mo/hu/rat p21 (WAF1/Cip1) poly has been tested by immunoblotting (WB) (1:200 starting dilution). Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
Specifications

Specifications

p21 (WAF1, Cip1)
Polyclonal
Unconjugated
CDKN1A
Liquid
CDKN1A
IgG
10 μg
4° C
Primary
1026, 114851, 12575
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
0.2 mg/mL
PBS with 0.2% gelatin and 0.1% sodium azide
P38936, P39689
CAP20, CDKN1, CDNK1A, MDA-6, SDI1, WAF1, p21CIP1, CDK-interacting protein 1, CDK-interaction protein 1, DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1, melanoma differentiation associated protein 6, wild-type p53-activated fragment 1
Rabbit
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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