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Tocris Bioscience™ Pexidartinib

Produktkod. 18717136
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Produktkod. Kvantitet
18717136 10 mg
18706716 50 mg
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Produktkod. 18717136 Leverantör Tocris Bioscience™ Leverantörsnummer 7590/10

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Beskrivning

Potent CSF-1R inhibitor

Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
CAS 1029044-16-3
Kvantitet 10 mg
Mål Additional RTK Inhibitors
Molekylformel C20H15ClF3N5
Renhet 98%
Titolo del prodotto
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