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STEMCELL Technologies Phorbol 12-myristate 13-acetate
Beskrivning
- Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg)
- PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.) PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker)
- Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.)
- Promotes hematopoietic differentiation (Clemens et al.)
- Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.)
- In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.)
Specifikationer
Specifikationer
| CAS | 16561-29-8 |
| Synonym | 12-O-Tetradecanoylphorbol-13-acetate;PMA;TPA |
| Kvantitet | 5 mg |
| Molekylformel | C36H56O8 |
| Renhet | ≥98% |
Produkttitel
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