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Invitrogen™ Phospho-DNA ligase IV (Thr650) Polyclonal Antibody
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Produktkod. 15702606
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Kvantitet:
100 μL
Förpackningsstorlek:
100µL
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15702606 100 μL 100µL
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Produktkod. 15702606 Leverantör Invitrogen™ Leverantörsnummer PA564535

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Rabbit Polyclonal Antibody

Phospho-DNA ligase IV (Thr650) Polyclonal Antibody detects endogenous levels of DNA ligase IV only when phosphorylated at Thr650.

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
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Specifikationer

Antigen Phospho-DNA ligase IV (Thr650)
Användningsområden Western Blot
Klassificering Polyclonal
Koncentration 1 mg/mL
Konjugera Unconjugated
Formulering PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gen LIG4
Genaccessionsnr. P49917
Gene Alias 5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Gensymboler LIG4
Värd art Rabbit
Immunogen A synthesized peptide derived from human DNA Ligase 4 (Phospho-Thr650).
Reningsmetod Antigen affinity chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 3981
Målarter Human
Innehåll och lagring -20°C
Produkttyp Antibody
Form Liquid
Isotyp IgG
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