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Phospho-ERK1/2 (Thr202, Tyr204) Mouse anti-Human, Mouse, Clone: MILAN8R, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9109-82

Additional Details : Weight : 0.09500kg

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Product Code. 15567576

  • 2690.00 SEK / 100µg


Estimated Shipment
04-01-2021
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Description

Description

Applications Tested: This MILAN8R antibody has been tested by immunoblotting of stimulated Jurkat cells and can be used at less than or equal to 5 μg/mL. This MILAN8R antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and by immunocytochemistry of MeOH-fixed cells and can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.
Specifications

Specifications

Phospho-ERK1/2 (Thr202, Tyr204)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q63844, P63085, P28482, P27361
Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 , MAPK1, ERK2, PRKM1, PRKM2, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, ERK1, PRKM3, p44, p42
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
MILAN8R
Unconjugated
MAPK1
Liquid
Mapk1, MAPK3
IgG1, kappa
100 μg
4° C
Primary
26413, 26417, 5594, 5595
Videos
SDS
Documents

For Research Use Only.