missing translation for 'onlineSavingsMsg'
Learn More

Phospho-LCK (Y505) Mouse anti-Human, Mouse, eFluor 660, Clone: SRRCHA, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9076-42

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15500077

  • 2572.00 SEK / 100 tests


Estimated Shipment date
from Supplier 04-01-2018
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

This SRRCHA monoclonal antibody recognizes human and mouse LCK when phosphorylated on tyrosine 505 (Y505). Y505 is a negative-regulatory site that is phosphorylated by the kinase CSK. LCK is expressed in T cells where it associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively. When the TCR is engaged, LCK acts to phosphorylate the intracellular chains of CD3 and zeta chains of the TCR complex, allowing the cytoplasmic tyrosine kinase, ZAP-70, to bind to them. LCK then phosphorylates and activates ZAP-70, which then phosphorylates the adaptor protein, LAT, that serves as a docking site for a number of other proteins, including SLP-76, Grb2, and phospholipase C gamma1. Mice lacking expression of LCK show defects in T cell development and function.
Specifications

Specifications

Phospho-LCK (Y505)
SRRCHA
eFluor 660
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
lymphocyte-specific protein tyrosine kinase, Leukocyte C-terminal Src kinase, p56lck
IgG1
RUO
Primary
Murine
Videos