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Phospho-ZAP-70/SYK (Y319/Y352) Mouse anti-Human, Mouse, APC, Clone: n3kobu5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-9006-42

Additional Details : Weight : 0.23750kg

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Product Code. 15508216

  • 2572.00 SEK / 100 tests


Estimated Shipment date
from Supplier 25-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

This n3kobu5 monoclonal antibody recognizes human and mouse zeta chain-associated protein of 70 kD (also known as ZAP-70) and spleen tyrosine kinase (also known as SYK) when phosphorylated on Y319 and Y352, respectively. ZAP-70 and SYK are members of the SYK protein tyrosine kinase (PTK) family that are phosphorylated and activated by Src family PTKs. ZAP-70/SYK Y319/Y352 are located in the so-called interdomain of ZAP-70/SYK (between the N-terminal dual SH2 domains and the C-terminal kinase domain).

Phosphorylation of ZAP-70 Y319 by Lck is necessary for T cell receptor (TCR)-dependent association of ZAP-70 with Lck and phospholipase C gamma and subsequent activation of calcium-dependent and Ras signaling cascades. SYK Y352 phosphorylation by Fyn/Lyn is critical for propagation of B cell receptor (BCR) signaling and for B cell development.

Specificity of this n3kobu5 clone was determined by ELISA, flow cytometry, and western blotting.
Specifications

Specifications

Phospho-ZAP-70/SYK (Y319/Y352)
n3kobu5
Allophycocyanin
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Zeta chain-associated protein of 70 kD/Spleen tyrosine kinase
IgG2b
RUO
Primary
Murine