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Tocris Bioscience™ PIK 90
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Produktkod. 30000011
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Produktkod. Kvantitet
30000011 10 mg
30000036 50 mg
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Produktkod. 30000011 Leverantör Tocris Bioscience™ Leverantörsnummer 7902/10

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Beskrivning

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo. PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.
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Specifikationer

Kemiskt namn eller material N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
CAS 677338-12-4
Kvantitet 10 mg
Mål PI 3-Kinase Inhibitors
Molekylformel C18H17N5O3
Renhet 0.98
Produkttitel
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